Uric Acid Levels and Sudomotor Dysfunction in Type 2 Diabetes
Author Information
Author(s): N. Papanas, M. Demetriou, N. Katsiki, K. Papatheodorou, D. Papazoglou, T. Gioka, S. Kotsiou, E. Maltezos, D. P. Mikhailidis
Primary Institution: Democritus University of Thrace
Hypothesis
Is there an association between serum uric acid levels and sudomotor dysfunction in patients with type 2 diabetes mellitus?
Conclusion
Patients with type 2 diabetes and sudomotor dysfunction have higher serum uric acid levels compared to those without this complication.
Supporting Evidence
- SUA levels were significantly higher in patients with sudomotor dysfunction.
- There was a significant correlation between SUA and Neuropad time to colour change.
- SUA levels correlated positively with CRP in both groups.
Takeaway
People with diabetes who have trouble sweating also have higher levels of a substance called uric acid in their blood.
Methodology
The study included 36 patients with sudomotor dysfunction and 40 matched patients without it, assessing serum uric acid levels and using the Neuropad test for diagnosis.
Potential Biases
Patients were recruited from a specialist unit, which may not represent the general population.
Limitations
The study was not prospective and had a relatively small sample size, limiting generalizability.
Participant Demographics
The mean age of participants was around 63 years, with both groups matched for age, gender, and diabetes duration.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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