Impact of Anterior Commissure on Glottic Cancer Treatment
Author Information
Author(s): Tong Chi-Chung, Au Kwok-Hung, Ngan Roger KC, Chow Sin-Ming, Cheung Foon-Yiu, Fu Yiu-Tung, Au Joseph SK, Law Stephen CK
Primary Institution: Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
Hypothesis
What prognostic factors influence local control of T1N0 glottic cancer treated by radiotherapy?
Conclusion
Involvement of the anterior commissure negatively impacts local control, but this can be mitigated by using a higher biologically effective dose through larger fraction sizes.
Supporting Evidence
- The 10-year local control rates were 91% for T1a and 87% for T1b.
- Poorly differentiated histology and anterior commissure involvement were significant adverse factors.
- A higher biologically effective dose can mitigate the negative impact of anterior commissure involvement.
Takeaway
Doctors studied patients with a type of throat cancer and found that if the cancer spreads to a specific area, it can be harder to treat, but using stronger doses of radiation can help.
Methodology
Retrospective review of medical records of 433 patients treated with radiotherapy using 6 MV photons.
Potential Biases
Potential bias due to lack of tumor volume measurements and the retrospective nature of the study.
Limitations
The study is retrospective and from a single institution, which may introduce bias.
Participant Demographics
95.3% male, 4.6% female; 74.8% T1a, 25.1% T1b.
Statistical Information
P-Value
0.011
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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