Identification of Nucleolin as New ErbB Receptors- Interacting Protein ErbB/Nucleolin Interactions
2008
Nucleolin's Role in ErbB Receptor Interactions
publication
Evidence: moderate
Author Information
Author(s): Di Segni Ayelet, Farin Keren, Pinkas-Kramarski Ronit
Primary Institution: Tel-Aviv University
Hypothesis
Nucleolin interacts with ErbB receptors and affects their activation and signaling.
Conclusion
Nucleolin enhances ErbB receptor dimerization and activation, leading to increased cell growth.
Supporting Evidence
- Nucleolin interacts with the cytoplasmic tail of ErbB4.
- Nucleolin enhances ErbB receptor dimerization and phosphorylation.
- Nucleolin reduces ligand-induced receptor degradation.
- Nucleolin promotes anchorage-independent growth in cells.
Takeaway
Nucleolin helps certain proteins in our cells talk to each other better, which can make cells grow more, especially in cancer.
Methodology
The study used GST-ErbB4 fusion protein pull down assay and mass spectroscopic analysis to identify interactions.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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