Pharmacokinetic Evaluation of Piper sarmentosum Extracts
Author Information
Author(s): Hussain Khalid, Ismail Zhari, Sadikun Amirin, Pazillah Ibrahim
Primary Institution: Universiti Sains Malaysia
Hypothesis
The study aimed to evaluate the pharmacokinetics of ethanol extract of Piper sarmentosum in rats.
Conclusion
Pellitorine and sarmentine have good oral bioavailability, while sarmentosine is not absorbed from the gastrointestinal tract.
Supporting Evidence
- Pellitorine exhibited maximum plasma concentration of 34.77 ng/mL.
- Sarmentine showed maximum plasma concentration of 191.50 ng/mL.
- Sarmentosine exhibited zero oral bioavailability.
- Pellitorine was distributed in multiple tissues including the liver and heart.
- Sarmentine was found in the intestinal wall and heart.
Takeaway
This study looked at how well certain compounds from a plant called Piper sarmentosum are absorbed and used by the body.
Methodology
The study used Sprague-Dawley rats to evaluate absorption, distribution, and excretion of the plant extracts through HPLC analysis.
Limitations
The study was limited to a small sample size and focused only on specific markers.
Participant Demographics
Male Sprague-Dawley rats, weighing approximately 313 ± 17 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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