CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death.
2024
CYP1B1-AS1 and its Role in Coxiella burnetii Infection
publication
Author Information
Author(s): Samuel James, Arunima Aryashree, Niyakan Seyednami, Butler Samantha, Clark Sabrina, Pinson Anna, Kwak Doyoung, Qian Xiaoning, de figueiredo Paul, Schaik Erin Van
Hypothesis
CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death.
Conclusion
CYP1B1-AS1 is identified as a potential target for combating Coxiella burnetii infection.
Supporting Evidence
- CYP1B1-AS1 was uniquely regulated during Cb infection.
- Inhibition of CYP1B1-AS1 and CYP1B1 increased reactive oxygen species and apoptosis.
- Immunoprecipitation identified CBU_0937 as an interactor of the CYP1B1 enzyme.
Takeaway
This study found that a specific RNA helps a germ survive in our cells by preventing cell death.
Methodology
A global transcriptomic approach was used to identify lncRNAs specific to Cb infection in THP-1 derived macrophages.
Digital Object Identifier (DOI)
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