Functions of Dishevelled 3 in Heart and Neural Development
Author Information
Author(s): Etheridge S. Leah, Ray Saugata, Li Shuangding, Hamblet Natasha S., Lijam Nardos, Tsang Michael, Greer Joy, Kardos Natalie, Wang Jianbo, Sussman Daniel J., Chen Ping, Wynshaw-Boris Anthony
Primary Institution: University of California San Diego
Hypothesis
What are the roles of Dishevelled 3 in cardiac outflow tract, cochlea, and neural tube development?
Conclusion
Dishevelled 3 is essential for cardiac outflow tract development and shows functional redundancy with Dishevelled 1 and 2 in various developmental processes.
Supporting Evidence
- Dvl3 knockout mice die perinatally with cardiac outflow tract abnormalities.
- Dvl3 functions redundantly with Dvl1 and Dvl2 in various developmental processes.
- Loss of Dvl3 leads to severe defects in heart and neural tube development.
- Adding Dvl1 or Dvl2 can rescue the lethal Dvl3 knockout phenotype.
Takeaway
Dishevelled 3 helps the heart and other body parts develop properly, and it can work together with similar proteins to fix problems when one is missing.
Methodology
The study involved generating mouse knockouts for each of the Dvl genes and analyzing their phenotypes.
Limitations
The study primarily focuses on mouse models, which may not fully represent human conditions.
Digital Object Identifier (DOI)
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