Expression and regulation of prostate androgen regulated transcript-1 (PART-1) and identification of differential expression in prostatic cancer
2001
Study of PART-1 Gene in Prostate Cancer
Sample size: 27
publication
Evidence: moderate
Author Information
Author(s): Sidiropoulos M, Chang A, Jung K, Diamandis E P
Primary Institution: Mount Sinai Hospital, Toronto, Ontario, Canada
Hypothesis
PART-1 may be implicated in prostate carcinogenesis or may be a potential new biomarker.
Conclusion
PART-1 is overexpressed in prostate cancer and may represent a novel prostate cancer tumor marker.
Supporting Evidence
- PART-1 is predominantly expressed in the prostate gland.
- PART-1 is regulated by androgens and other hormones.
- PART-1 shows similarity to prostate-specific antigen (PSA).
- PART-1 is expressed in various tissues including the thymus and placenta.
- PART-1 is more frequently overexpressed in cancerous prostatic tissue.
Takeaway
The PART-1 gene is found more in prostate cancer tissues than in normal ones, which might help doctors find new ways to detect prostate cancer.
Methodology
Reverse transcriptase polymerase chain reaction (RT-PCR) was used to study PART-1 expression in paired cancerous and non-cancerous prostatic tissues.
Digital Object Identifier (DOI)
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