Correlation of neomycin, faecal neutral and acid sterols with colon carcinogenesis in rats
1999
Study on Neomycin and High Fat Diets in Colon Cancer in Rats
publication
Evidence: moderate
Author Information
Author(s): Panda S K, Chattoraj S C, Broitman S A
Primary Institution: Maharaja Manindra Chandra College, Calcutta, India; Boston University School of Medicine, USA
Hypothesis
The study investigates the relationship between high fat diets, neomycin, and colon carcinogenesis in rats.
Conclusion
Coprostanol may be associated with colon carcinogenesis in rats fed a high fat diet and neomycin.
Supporting Evidence
- Neomycin was associated with both an increase and decrease in tumor numbers.
- Coprostanol showed a significant positive correlation with tumorigenesis in all dietary groups.
- Cholesterol and cholic acid levels decreased with an increase in tumor numbers.
Takeaway
This study looked at how certain diets and a drug called neomycin affect cancer in rats, finding that a specific substance in their poop might be linked to cancer.
Methodology
Rats were fed different high fat diets and treated with DMH to evaluate tumor incidence and faecal sterol metabolism.
Participant Demographics
Rats were used in the study.
Digital Object Identifier (DOI)
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