Increased Anti-Anisakis Antibodies in Septic Patients
Author Information
Author(s): Andreu-Ballester Juan Carlos, Navarro Amparo, Arribas Miguel Angel, Rico Moises, Albert Laura, García-Ballesteros Carlos, Galindo-Regal Lorena, Sorando-Serra Rosa, López-Chuliá Francisca, Peydro Federico, Rodero Marta, González-Fernández Juan, Cuéllar Carmen
Primary Institution: FISABIO Foundation–Public Health of Valencia
Hypothesis
The study aims to analyze the evolution of anti-Anisakis immunoglobulins in septic patients during hospital admission and their association with T cell subsets.
Conclusion
The study found that anti-Anisakis IgG and IgA levels increased during hospital admission in septic patients, suggesting a previous infection could be involved in the septic process.
Supporting Evidence
- Anti-Anisakis IgG and IgA levels were higher in septic patients compared to healthy controls.
- Patients with septic shock showed a significant increase in anti-Anisakis IgG positivity.
- Surviving patients had increased levels of anti-Anisakis antibodies during hospital admission.
Takeaway
The study shows that patients with sepsis have higher levels of certain antibodies, which might mean they had a previous infection with a parasite called Anisakis.
Methodology
The study recruited 80 participants, including 40 septic patients and 40 healthy controls, and analyzed T cell subsets and anti-Anisakis antibodies using flow cytometry and ELISA.
Limitations
The study did not include patients with immune system deficiencies or those undergoing immunosuppressive therapy.
Participant Demographics
Participants included 40 septic patients and 40 healthy controls matched by sex and age.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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