In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
1999
Effects of Combretastatin A-4 on Colon Tumors
publication
Evidence: moderate
Author Information
Author(s): Grosios K, Holwell S E, McGown A T, Pettit G R, Bibby M C
Primary Institution: Clinical Oncology Unit, University of Bradford
Hypothesis
Combretastatin A-4 and its prodrug will demonstrate anti-tumor effects in colon cancer models.
Conclusion
Combretastatin A-4 and its prodrug caused extensive necrosis in colon cancer tumors and metastases, indicating a vascular mechanism of action.
Supporting Evidence
- Combretastatin A-4 caused almost complete vascular shutdown in colon tumors.
- Extensive hemorrhagic necrosis was observed starting 1 hour after treatment.
- Significant tumor growth delay was noted in treated colon tumors.
- The prodrug also showed similar vascular effects in human colon tumor xenografts.
Takeaway
Combretastatin A-4 can make cancer tumors die by cutting off their blood supply.
Methodology
The study evaluated the effects of combretastatin A-4 and its prodrug in colon tumor models and endothelial cell cultures.
Digital Object Identifier (DOI)
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