PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading
2006
PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading
publication
Evidence: moderate
Author Information
Author(s): Marie P. J., Kaabeche K.
Primary Institution: Laboratory of Osteoblast Biology and Pathology, INSERM U606, University of Paris 7
Hypothesis
PPARγ plays an important role in the control of osteoblastogenesis and bone mass in skeletal unloading.
Conclusion
Manipulation of PPARγ may correct the balance between osteoblastogenesis and adipogenesis and prevent bone loss.
Supporting Evidence
- PPARγ positively promotes adipogenesis and negatively regulates osteoblast differentiation.
- Skeletal unloading leads to decreased osteoblast differentiation and increased adipocyte differentiation.
- Exogenous TGF-β2 can inhibit adipogenesis and promote osteoblastogenesis.
Takeaway
When bones don't bear weight, they lose mass because the cells that build bone are not working well, and a fat-producing process takes over. A protein called PPARγ is involved in this process.
Methodology
The review summarizes current knowledge on PPARγ's role in bone cell differentiation and bone mass control during skeletal unloading.
Digital Object Identifier (DOI)
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