P53 Abnormalities and Colorectal Cancer Outcomes
Author Information
Author(s): Munro A J, Lain S, Lane D P
Primary Institution: Department of Surgery and Molecular Oncology, University of Dundee
Hypothesis
Are patients whose tumours contain abnormal p53 more likely to die than patients whose p53 is normal?
Conclusion
Patients with abnormal p53 are at increased risk of death, especially those with a better underlying prognosis.
Supporting Evidence
- Patients with abnormal p53 had a relative risk of death of 1.32 when assessed by immunohistochemistry.
- Abnormal p53 was associated with failure of response to radiotherapy in rectal cancer patients.
- The adverse impact of abnormal p53 was greater in patients with lower baseline risk of dying.
Takeaway
If a person's cancer has a messed-up p53 gene, they might not do as well as someone whose p53 gene is normal, especially if they were already at a lower risk of dying.
Methodology
A systematic review of studies assessing the effect of p53 abnormalities on prognosis in colorectal cancer patients, using immunohistochemistry and sequence analysis.
Potential Biases
Evidence of publication bias that may exaggerate the adverse effect of p53 abnormalities on survival.
Limitations
Variability in p53 status assessment and reporting of results, along with evidence of publication bias.
Participant Demographics
Data from 18,766 patients across 168 studies.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% confidence interval (1.23–1.42)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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