Interferon-7 stimulates monocyte chemotactic protein-1 expression by monocytes
1994
IFN-y Stimulates Monocyte Chemotactic Protein-1 Expression
Sample size: 7
publication
Evidence: moderate
Author Information
Author(s): J. M. Liebler, S. L. Kunkel, R. M. Allen, M. D. Burdick, R. M. Strieter
Primary Institution: University of Michigan Medical School
Hypothesis
What conditions lead human monocytes to express MCP-1?
Conclusion
IFN-y stimulates the expression of MCP-1 by monocytes, while IL-1, TNF, and IL-4 do not.
Supporting Evidence
- Monocytes did not produce MCP-1 in response to IL-1, TNF, or IL-4.
- Stimulation with IFN-y resulted in a dose-dependent increase in MCP-1 protein and mRNA expression.
- Simultaneous stimulation with IFN-y and IL-1 or TNF did not further increase MCP-1 production.
Takeaway
This study found that a substance called IFN-y helps certain immune cells called monocytes produce a protein that attracts more immune cells to areas of inflammation.
Methodology
Monocytes were isolated from healthy volunteers and stimulated with various cytokines to measure MCP-1 production.
Participant Demographics
Healthy volunteers provided blood samples.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
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