Risk Factors for Blood Clots in Acute Promyelocytic Leukemia

Sample size: 155 publication 10 minutes Evidence: moderate

Author Information

Author(s): Sabljic Nikica, Pantic Nikola, Virijevic Marijana, Rajic Jovan, Cvetkovic Mirjana, Trajkovic Lazar, Pravdic Zlatko, Bukumiric Zoran, Suvajdzic Vukovic Nada, Bogdanovic Andrija, Vidovic Ana, Todorovic Balint Milena, Bila Jelena, Lekovic Danijela, Djunic Irena, Antic Darko, Mitrovic Mirjana

Primary Institution: University Clinical Center of Serbia

Hypothesis

What are the risk factors for venous thromboembolism (VTE) in patients with acute promyelocytic leukemia (APL)?

Conclusion

Higher expression of CD114 increases the risk of VTE in patients with APL.

Supporting Evidence

Among the 155 patients, 28 (18.1%) had VTEs.
CD114 expression was identified as an independent risk factor for VTE.
The absence of bleeding at presentation correlated with a higher risk of thrombosis.
Neither the Al-Ani RAM nor the Paterno RAM predicted VTEs in this cohort.

Takeaway

This study found that some patients with a type of blood cancer called APL are more likely to develop blood clots, especially if they have a certain protein called CD114 in higher amounts.

Methodology

A retrospective study analyzing demographic and clinical-laboratory data of adult APL patients treated with all-trans retinoic acid and anthracycline.