Antifungal Activities of Peptides from High-Molecular-Weight Kininogen
Author Information
Author(s): Andreas Sonesson, Emma Andersson, Martin Malmsten, Artur Schmidtchen
Primary Institution: Lund University
Hypothesis
Do D5-derived peptides from high-molecular-weight kininogen exhibit antifungal activity?
Conclusion
The study found that D5-derived peptides from high-molecular-weight kininogen can effectively kill Candida and Malassezia, with enhanced activity observed in modified peptides.
Supporting Evidence
- D5-derived peptides showed potent antifungal activity against Candida and Malassezia.
- Modified peptides exhibited enhanced antifungal effects in physiological conditions.
- Fluorescence microscopy confirmed binding of HKH20 to the fungal cell membrane.
Takeaway
Scientists discovered that certain peptides from a protein in the blood can kill harmful fungi that cause skin infections.
Methodology
The study involved incubating high-molecular-weight kininogen with neutrophil elastase to generate peptides, which were then tested for antifungal activity against Candida and Malassezia.
Limitations
Further investigations are needed to fully understand the generation of D5 peptides in response to fungal infection.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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