Chemoradiotherapy in Elderly Patients with Oesophageal Cancer
Author Information
Author(s): Tougeron D, Di Fiore F, Thureau S, Berbera N, Iwanicki-Caron I, Hamidou H, Paillot B, Michel P
Primary Institution: Rouen University Hospital
Hypothesis
The study aims to evaluate the tolerance and outcome of elderly patients older than 70 years treated with chemoradiotherapy for non-metastatic oesophageal cancer.
Conclusion
Chemoradiotherapy could be considered an effective treatment without major toxicity in elderly patients with oesophageal cancer.
Supporting Evidence
- A clinical complete response was observed in 63 patients (57.8%).
- Two-year survival rate was 35.5%.
- Adverse events grade 3 or higher were observed in 26 patients (23.8%).
- Chemotherapy dose reduction was necessary in 33 patients (30.3%).
- Median overall survival was 15.2 months.
Takeaway
Doctors studied how well older people handle a specific cancer treatment and found it works well without causing too many problems.
Methodology
The study included consecutive patients over 70 years with non-metastatic oesophageal cancer treated with definitive chemoradiotherapy, evaluating clinical complete response and survival rates.
Potential Biases
Potential selection bias as the study included only patients treated at a single institution.
Limitations
The study is retrospective and may not reflect outcomes in a broader population due to selection bias.
Participant Demographics
Patients were aged 70 to 88 years, with a mean age of 74.4 years; 34.9% were over 75 years.
Statistical Information
P-Value
P<0.01
Confidence Interval
95% CI: 30.8–40.2
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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