BAFF and Its Role in Th17 Cells and Autoimmune Disease
Author Information
Author(s): Zhou Xiaohui, Xia Zanxian, Lan Qin, Wang Julie, Su Wenru, Han Yuan-Ping, Fan Huimin, Liu Zhongmin, Stohl William, Zheng Song Guo
Primary Institution: University of Southern California Keck School of Medicine
Hypothesis
The study aims to determine the effect of BAFF on Th17 cell generation and its implications for experimental autoimmune encephalomyelitis (EAE).
Conclusion
BAFF contributes to pathogenic Th17 cell responses, suggesting that targeting BAFF may be beneficial in treating Th17 cell-driven diseases.
Supporting Evidence
- BAFF-Tg mice showed increased Th17 cell generation compared to B6 WT mice.
- BAFF deficiency in B6.Baff−/− mice resulted in decreased Th17 cell generation.
- EAE was most severe in BAFF-Tg mice and least severe in B6.Baff−/− mice.
Takeaway
BAFF helps certain immune cells called Th17 cells grow, which can make diseases like multiple sclerosis worse.
Methodology
The study involved using various genetically modified mice to assess the effects of BAFF on Th17 cell generation and EAE severity.
Statistical Information
P-Value
p≤0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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