3-[Bis(p-tolylsulfonyl)amino]-N-(4-chlorobenzyl)-6-(3,4-dichlorophenyl)thieno[2,3-b]pyridine-2-carboxamide
2011
Crystal Structure of a Thieno[2,3-b]pyridine Derivative
publication
Evidence: high
Author Information
Author(s): He Hai-Yun, Li Hong-Ze, Yang Li
Primary Institution: West China Hospital, West China Medical School, Sichuan University
Hypothesis
The study investigates the crystal structure of a specific thieno[2,3-b]pyridine derivative.
Conclusion
The crystal structure reveals that the molecular conformation is stabilized by an intramolecular hydrogen bond and that molecules are linked into chains by intermolecular hydrogen bonds.
Supporting Evidence
- The dihedral angle between the thieno[2,3-b]pyridine ring and the attached benzene ring is very small at 3.89°.
- The molecular conformation is stabilized by an intramolecular N—H⋯O hydrogen bond.
- Molecules in the crystal are linked by intermolecular C—H⋯O hydrogen bonds.
Takeaway
Scientists looked at how a certain chemical compound is arranged in a crystal. They found that the way the atoms are connected helps keep the structure stable.
Methodology
The crystal structure was determined using X-ray diffraction techniques.
Digital Object Identifier (DOI)
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