Immune Cell Traits and Plasma Metabolites in Colorectal Cancer
Author Information
Author(s): Zhu Liye, Ning Qiting, Xue Jiang, Huang Shanpei, Chen Xingmei, Qiu Xinze, Chen Ni, Liang Shengmei, Huang Jiean, Liu Shiquan
Primary Institution: The Second Affiliated Hospital of Guangxi Medical University
Hypothesis
Do immune cell traits mediate the causal relationship between plasma metabolites and colorectal cancer?
Conclusion
The study identifies a causal relationship between plasma metabolites and colorectal cancer, with immune factors playing mediating roles.
Supporting Evidence
- 49 plasma metabolites were found to have causal associations with colorectal cancer.
- 36 immune cell traits were identified as causally linked to colorectal cancer.
- Two immune cell traits were found to mediate the effects of specific plasma metabolites on colorectal cancer risk.
Takeaway
This study found that certain substances in the blood can affect the risk of colorectal cancer by influencing immune cells.
Methodology
The study used a two-step Mendelian randomization approach and single-cell RNA sequencing to analyze the relationships between plasma metabolites, immune cell traits, and colorectal cancer.
Potential Biases
Potential heterogeneity and horizontal pleiotropy may not have been fully assessed.
Limitations
The study's conclusions are limited to European populations, and further validation in other populations is needed.
Participant Demographics
All samples were from Western populations.
Statistical Information
P-Value
0.036
Confidence Interval
[95% CI [-0.023, 0.054]]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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