RANTES Gene Polymorphisms and Myocardial Infarction in Slavonic Patients
Author Information
Author(s): Irina P. Tereshchenko, Jana Petrkova, Mikhail I. Voevoda, Milos Taborsky, Zdenka Navratilova, Aida G. Romaschenko, Vladimir N. Maksimov, Frantisek Mrazek, Martin Petrek
Primary Institution: Institute of Molecular and Translational Medicine, Palacky University and Faculty Hospital
Hypothesis
Are RANTES gene polymorphisms associated with myocardial infarction in Slavonic populations?
Conclusion
The study found no significant association between RANTES gene polymorphisms and myocardial infarction in the examined populations.
Supporting Evidence
- Both RANTES genotypes and allele frequencies did not differ between case and control groups.
- Haplotype-based analysis also failed to reveal an association between MI and investigated markers.
- Strong linkage disequilibrium was detected between particular RANTES alleles.
Takeaway
The researchers looked at two specific gene changes in people who had heart attacks and found that these changes didn't seem to make a difference.
Methodology
The study involved genotyping RANTES gene polymorphisms in 467 myocardial infarction patients and 337 control subjects using PCR-SSP.
Limitations
The study may not be generalizable beyond the Slavonic populations examined.
Participant Demographics
804 unrelated Caucasian individuals, including 467 myocardial infarction patients and 337 healthy controls.
Statistical Information
Confidence Interval
95% CI 0.740–1.340 for RANTES -403A and 95% CI 0.759–1.464 for RANTES In1.1C
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
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