Reactive Metabolite Target Protein Database (TPDB)
Author Information
Author(s): Hanzlik Robert P, Koen Yakov M, Theertham Bhargav, Dong Yinghua, Fang Jianwen
Primary Institution: University of Kansas
Hypothesis
Different pro-toxins target a common subset of proteins whose covalent modification might be mechanistically significant to cytotoxicity.
Conclusion
The TPDB is a unique online compilation of information on the covalent modification of cellular proteins by reactive metabolites of chemicals and drugs.
Supporting Evidence
- The TPDB contains 152 hits comprising 121 non-redundant proteins.
- The database is freely accessible on the web.
- It allows for complex searches by selecting chemical compound, animal species, target tissue, and protein names.
Takeaway
The TPDB is a website that helps scientists find out which proteins are affected by harmful chemicals, making it easier to understand how these chemicals can be toxic.
Methodology
The TPDB was created using an Oracle 9i relational database and includes data from literature reports of specific identifications of target proteins for reactive metabolites.
Limitations
The database currently does not include information about oxidative damage to proteins or modifications by endogenous products of lipid peroxidation.
Participant Demographics
Most data came from experiments done in mice or rats, with a few human observations included.
Digital Object Identifier (DOI)
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