Tacrine's Effect on Lower Oesophageal Sphincter in Pigs
Author Information
Author(s): Bures Jan, Novak Martin, Radochova Vera, Kohoutova Darina, Prchal Lukas, Martinek Jan, Mares Jan, Cerny Jaroslav, Suchanek Stepan, Pejchal Jaroslav, Voxova Barbora, Urbanek Petr, Zavoral Miroslav, Soukup Ondrej
Primary Institution: Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic
Hypothesis
Does tacrine affect the functional response of the lower oesophageal sphincter in experimental pigs?
Conclusion
Tacrine did not compromise the function of the lower oesophageal sphincter in experimental pigs.
Supporting Evidence
- Tacrine is a non-competitive reversible acetylcholinesterase inhibitor.
- The study used endoscopic luminal impedance planimetry to measure the lower oesophageal sphincter response.
- Results showed an increase in luminal pressure after tacrine administration.
- Distensibility and cross-sectional area remained within normal ranges after treatment.
- The study is the first to assess the impact of a cholinesterase inhibitor on the lower oesophageal sphincter using this method.
Takeaway
This study looked at how a drug called tacrine affects a part of the pig's stomach. It found that tacrine doesn't hurt that part of the stomach.
Methodology
Six experimental pigs were used, and various parameters were measured before and after administering 200 mg of tacrine.
Potential Biases
There may be a risk of bias due to the small sample size and the specific demographic of the pigs used.
Limitations
The study was conducted on young adult female pigs without previous interventions, which may limit the applicability of the results to other populations.
Participant Demographics
Six experimental female adult pigs, mean weight 32.9 ± 3.5 kg.
Digital Object Identifier (DOI)
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