Lysophosphatidylcholines and Alzheimer's Disease
Author Information
Author(s): Arbeev Konstantin, Bagley Olivia, Ukraintseva Svetlana, Cosentino Stephanie, Kulminski Alexander, Stallard Eric, Yashin Anatoliy
Primary Institution: Duke University
Hypothesis
What is the relationship between longitudinal changes in lysophosphatidylcholines levels and Alzheimer's disease risk?
Conclusion
The study found a sex-specific relationship between lysophosphatidylcholines dynamics and Alzheimer's disease incidence in males.
Supporting Evidence
- The study analyzed 4,017 measurements of 23 LPC species.
- There were 93 incident AD cases among the participants.
- The strongest association was found for LPC(14:0/0:0) in males.
Takeaway
This study looked at how certain fats in the body might be linked to Alzheimer's disease, especially in men.
Methodology
Statistical approaches for joint analyses of longitudinal and time-to-event outcomes were applied.
Participant Demographics
Participants were from the U.S. and included both males and females.
Statistical Information
P-Value
2.3e-23
Statistical Significance
p=2.3e-23
Digital Object Identifier (DOI)
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