Consanguinity and Cancer Risk
Author Information
Author(s): Denic S, Bener A
Primary Institution: UAE University
Hypothesis
Does consanguinity affect the risk of breast and cervical cancer among women?
Conclusion
Having consanguineous parents decreases the risk of breast cancer, especially in younger women, while the risk of cervical cancer remains unaffected.
Supporting Evidence
- Among 579 women of consanguineous parents, 24 had breast cancer compared to 54 of 866 women of non-consanguineous parents.
- In the 40 to 50 age group, 13 of 446 women of consanguineous parents reported breast cancer compared to 37 of 633 non-consanguineous parents.
- Cervical cancer was reported in 15 women of consanguineous parents and 32 of non-consanguineous parents.
Takeaway
If your parents are cousins, you might have a lower chance of getting breast cancer, but it doesn't change your chances of getting cervical cancer.
Methodology
The study involved face-to-face interviews with married female citizens aged 40-65 in the UAE, assessing their family history of consanguinity and cancer.
Potential Biases
Potential bias in self-reported data regarding cancer history.
Limitations
The study may not account for all genetic and environmental factors influencing cancer risk.
Participant Demographics
Married female citizens aged 40-65 from the United Arab Emirates.
Statistical Information
P-Value
0.29
Confidence Interval
0.42–1.06 for breast cancer risk in consanguineous vs non-consanguineous groups.
Statistical Significance
p=0.29
Digital Object Identifier (DOI)
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