Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis
2025

Impact of Regenerative Procedure on Healing After Root Canal Treatment

Sample size: 690 publication 10 minutes Evidence: moderate

Author Information

Author(s): Muthanna Nader, Guan Xiaoyue, Alzahrani Fouad, Saif Badr Sultan, Seyam Abdelrahman, Alsalman Ahmed, Alajami Ahmed Es, Li Ang

Primary Institution: Xi’an Jiaotong University, Xi’an, China

Hypothesis

This study aimed to evaluate the impact of regenerative procedures on the healing process following surgical root canal treatment.

Conclusion

GTR significantly improved healing after surgical root canal treatment, especially when collagen membranes and bovine bone-derived hydroxyapatite were used together.

Supporting Evidence

  • GTR procedures significantly improved healing after surgical root canal treatment.
  • Collagen membranes combined with bovine bone-derived hydroxyapatite enhanced the healing process.
  • The study included 16 randomized controlled trials with a total of 690 lesions.

Takeaway

Using special techniques and materials can help heal teeth better after surgery.

Methodology

A systematic review and meta-analysis of randomized controlled trials evaluating GTR procedures after surgical root canal treatment.

Potential Biases

Some concerns regarding randomization and selective reporting in several studies.

Limitations

Some studies had concerns regarding risk of bias, and only a few used 3D evaluation methods.

Participant Demographics

Patients undergoing surgical root canal treatment with varying lesion types.

Statistical Information

P-Value

<0.001

Confidence Interval

95% CI, 0.34–0.73

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1371/journal.pone.0312751

Want to read the original?

Access the complete publication on the publisher's website

View Original Publication