Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster
2011

Red Mold Rice Reduces Oral Cancer in Hamsters

Sample size: 5 publication 10 minutes Evidence: moderate

Author Information

Author(s): Ruei-Lan Tsai, Ho Bing-Ying, Pan Tzu-Ming

Primary Institution: National Taiwan University

Hypothesis

Does red mold rice have an anti-tumor effect on DMBA-induced oral cancer in hamsters?

Conclusion

Red mold rice significantly reduces tumor burden and levels of harmful substances in hamsters with oral cancer.

Supporting Evidence

  • Red mold rice treatment significantly decreased tumor burden compared to the control group.
  • RMRE reduced levels of reactive oxygen species and other harmful substances in the oral tissue of hamsters.
  • RMRE was more effective than lovastatin in reducing tumor formation.

Takeaway

Red mold rice can help prevent oral cancer in hamsters by reducing harmful substances in the body.

Methodology

Hamsters were treated with DMBA to induce oral tumors and then given red mold rice extract to evaluate its effects on tumor formation and related biochemical markers.

Limitations

The study was conducted on hamsters, which may not fully represent human responses.

Participant Demographics

Five-week-old male Syrian golden hamsters were used in the study.

Statistical Information

P-Value

p<0.001

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1093/ecam/nep215

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