Diet-Induced Weight Loss and Lipid Changes in People with Abnormal Glucose Metabolism
Author Information
Author(s): Ursula Schwab, Tuulikki Seppänen-Laakso, Laxman Yetukuri, Jyrki Ågren, Marjukka Kolehmainen, David E. Laaksonen, Anna-Liisa Ruskeepää, Helena Gylling, Matti Uusitupa, Matej Orešič
Primary Institution: University of Kuopio, Kuopio, Finland
Hypothesis
The diet-induced weight loss affects the global plasma lipidomic profile.
Conclusion
Diet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism.
Supporting Evidence
- Body weight decreased in the weight reduction group by 7.8±2.9%.
- Most serum triacylglycerols and phosphatidylcholines were reduced.
- The decrease in triacylglycerols correlated with the increase of insulin sensitivity.
- Levels of several longer chain fatty acids were not affected by weight loss.
Takeaway
When people lose weight by changing their diet, their blood fats change too, which can help them use insulin better.
Methodology
Plasma samples from 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses over a 33-week intervention.
Limitations
The clinical characteristics of the two groups were not entirely similar at baseline, and the small sample size may have masked other potential changes.
Participant Demographics
75 overweight or obese subjects aged 40 to 70 years with impaired fasting glucose or impaired glucose tolerance.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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