New Genetic Link for Diabetic Nephropathy in Type 1 Diabetes
Author Information
Author(s): Wessman Maija, Forsblom Carol, Kaunisto Mari A., Söderlund Jenny, Ilonen Jorma, Sallinen Riitta, Hiekkalinna Tero, Parkkonen Maija, Maxwell Alexander P., Tarnow Lise, Parving Hans-Henrik, Hadjadj Samy, Marre Michel, Peltonen Leena, Groop Per-Henrik
Primary Institution: Folkhälsan Research Center, Folkhälsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland
Hypothesis
The study aimed to identify new susceptibility loci for diabetic nephropathy in families with type 1 diabetes.
Conclusion
A novel susceptibility locus for diabetic nephropathy was identified at chromosome 22q11, which may be significant in European populations.
Supporting Evidence
- Diabetic nephropathy affects about 30% of patients with type 1 diabetes.
- Genome-wide linkage analysis identified a significant LOD score of 3.58 at the 22q11 locus.
- Suggestive evidence of linkage was also found at six additional loci in the Finnish and French sample sets.
Takeaway
Researchers found a new spot in our genes that might make some people with type 1 diabetes more likely to have kidney problems.
Methodology
A genome-wide linkage study was performed using 384 microsatellite markers across 175 families with type 1 diabetes.
Limitations
The sample size may limit the power to detect susceptibility loci with moderate effects.
Participant Demographics
Participants included 175 families from Finland, Denmark, and France, with a total of 556 individuals.
Statistical Information
P-Value
9.8·10−7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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