Genetics of Gene Expression Variation in Humans
Author Information
Author(s): Vivian G Cheung, Richard S Spielman
Primary Institution: The Children's Hospital of Philadelphia
Hypothesis
What are the genetic factors contributing to variation in gene expression levels among individuals?
Conclusion
The data provided for Problem 1 offer a unique opportunity for analysis of genetics of variation in expression levels of a large number of genes.
Supporting Evidence
- The study utilized data from 14 three-generation CEPH families.
- Gene expression data were obtained for 3554 genes.
- 2882 single-nucleotide polymorphism genotypes were provided for each family member.
Takeaway
This study looks at how different people's genes express themselves in unique ways, using data from large families to understand why that happens.
Methodology
Data were collected from 14 three-generation CEPH families and 30 HapMap trios, focusing on gene expression levels and genotypes.
Limitations
The data sets continue to be updated and were not provided separately for GAW15.
Participant Demographics
Data from 14 CEPH Utah families and 30 HapMap trios.
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