Selenium Intake and Spontaneous Abortion: The Role of FTO Genotype
Author Information
Author(s): Nooriani Narjes, Saeedirad Zahra, Shekari Soheila, Nami Sheyda, Mahmoudi Zahra, Abbasi Mobarakeh Khadijeh, Adabi Somayyeh Bararnia, Khodarahmi Shiva, Bahmani Parsa, Doaei Saeid, Ajami Marjan, Gholamalizadeh Maryam
Primary Institution: Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hypothesis
This research assessed the potential interactions between the risk of spontaneous abortion, dietary selenium intake, and the FTO rs9939609 polymorphism.
Conclusion
A link may exist between selenium consumption and spontaneous abortion, especially in individuals with the TT genotype in the FTO gene.
Supporting Evidence
- A lower selenium intake was inversely associated with spontaneous abortion only among individuals with the TT genotype of the FTO gene.
- The findings showed that there were no significant variations in dietary selenium intake between case and control groups.
- Further investigation is required to validate these conclusions.
Takeaway
Eating enough selenium might help prevent miscarriages, especially for some women with a specific gene type.
Methodology
This case-control study included 192 women who experienced spontaneous abortion and 347 control participants, assessing dietary selenium intake and genotyping the FTO gene.
Potential Biases
Potential recall bias in dietary reporting and selection bias from a single hospital setting.
Limitations
The study's reliance on self-reported dietary intake may introduce recall bias, and the sample was drawn from a single hospital, limiting generalizability.
Participant Demographics
Women aged 20-40, with 192 cases of spontaneous abortion and 347 controls.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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