Islet Hemorrhage Induced by Diagnostic Ultrasound in Rat Pancreas
Author Information
Author(s): Miller Douglas L., Dou Chunyan, Sorenson Dorothy, Liu Ming
Primary Institution: University of Michigan Health System, Ann Arbor, Michigan, United States of America
Hypothesis
This study aimed to histologically examine and characterize the possible occurrence of capillary hemorrhage in rat pancreas, particularly in islets, induced by contrast-enhanced diagnostic ultrasound (CEDUS).
Conclusion
Diagnostic ultrasound with a contrast agent induced significant islet hemorrhage in rat pancreas.
Supporting Evidence
- 76.2±11.8% of islets had evidence of hemorrhage in CEDUS pancreata compared to 1.1±2.5% in sham CEDUS.
- The percentage of islets with hemorrhage decreased with decreasing peak rarefactional pressure amplitude.
- Blood insulin levels significantly increased after CEDUS treatment compared to sham.
Takeaway
The study found that using special ultrasound with a contrast agent can cause bleeding in the tiny parts of the pancreas that help control blood sugar.
Methodology
The pancreata of anesthetized hairless rats were accessed by laparotomy and scanned with a diagnostic ultrasound probe while infused with a contrast agent, followed by histological examination.
Limitations
The study was conducted in rats, and the results may not directly translate to humans.
Participant Demographics
Hairless rats (CD strain, Charles River, Wilmington, MA, USA) aged 8–10 weeks.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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