Probiotic Lactiplantibacillus plantarum 1008 Improves Reproductive and Cognitive Functions in Aged Obese Mice
Author Information
Author(s): Liu Chin-Yu, Tsai Tsung-Yu, Liu Te-Hua, Chang Ting-Chia, Chen Yi-Wen, Tsao Chih-Wei
Primary Institution: Fu Jen Catholic University
Hypothesis
The study investigates the effects of Lactiplantibacillus plantarum 1008 on reproductive function and cognitive activity in aged male mice with obesity induced by a high-fat diet.
Conclusion
Lactiplantibacillus plantarum 1008 treatment improved reproductive function, cognitive activity, and metabolic parameters in aged male mice with high-fat-diet-induced obesity.
Supporting Evidence
- LP1008 treatment improved sperm quality and testosterone levels in aged, obese male mice.
- Spatial learning and memory were enhanced in mice treated with LP1008 compared to controls.
- LP1008 reduced oxidative stress and inflammation in testicular tissues of treated mice.
- Histological analysis showed improved brain morphology in LP1008-treated mice.
Takeaway
This study shows that a probiotic can help older mice with obesity think better and have healthier reproductive systems.
Methodology
The study used a high-fat diet to induce obesity in male mice, which were then treated with low and high doses of LP1008 for 8 weeks, followed by various assessments of reproductive and cognitive functions.
Potential Biases
Potential bias in the selection of treatment doses and the specific mouse model used.
Limitations
The study was conducted on mice, and results may not directly translate to humans; the long-term effects of LP1008 treatment were not assessed.
Participant Demographics
Male C57BL/6 mice, aged 36 weeks at the start of the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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