Effects of Basic Fibroblast Growth Factor on Tumor Hypoxia
Author Information
Author(s): J.T. Leith, Seth Michelson
Primary Institution: Brown University School of Medicine
Hypothesis
How does administration of basic fibroblast growth factor (FGF-2) affect hypoxic fractions in xenografted DLD-2 human tumors over time?
Conclusion
FGF-2 administration prevents the increase in hypoxic percentages in DLD-2 tumors, maintaining lower levels even after treatment ends.
Supporting Evidence
- FGF-2 treatment resulted in a significant decrease in hypoxic cells from about 42% to about 19%.
- The hypoxic percentage in FGF-2 treated tumors remained low even after treatment ended.
- FGF-2 treated tumors showed a 33% increase in cardiac output compared to control tumors.
Takeaway
Giving a special growth factor to mice with tumors helps keep the tumors from getting too low on oxygen, which is good for their growth.
Methodology
Mice were treated with FGF-2 and tumor growth and hypoxic fractions were measured over time.
Limitations
The study did not explicitly study the effects of nonequivalent tumor volumes on hypoxia interpretation.
Participant Demographics
Young adult male mice were used in the study.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% confidence limits
Statistical Significance
p<0.05
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