Elevated Expression of Phospholipid Transfer Protein in Bone Marrow Derived Cells Causes Atherosclerosis
Author Information
Author(s): van Haperen Rien, Samyn Hannelore, Moerland Matthijs, van Gent Teus, Peeters Marian, Grosveld Frank, van Tol Arie, de Crom Rini
Primary Institution: Erasmus MC University Medical Center, Rotterdam, The Netherlands
Hypothesis
The study aims to evaluate the atherogenic potential of macrophage derived phospholipid transfer protein (PLTP).
Conclusion
PLTP expression by bone marrow derived cells results in increased atherosclerosis and altered plasma lipid levels.
Supporting Evidence
- Macrophages from PLTP transgenic mice secrete increased levels of PLTP.
- Bone marrow transplantation from PLTP transgenic mice leads to increased plasma PLTP activity.
- PLTP overexpression results in decreased HDL cholesterol and increased non-HDL cholesterol.
- Atherosclerosis increased by 2.3 to 4.5-fold in mice receiving PLTP transgenic bone marrow.
Takeaway
Mice with more of a certain protein from bone marrow cells got more heart disease, showing that this protein can be bad for heart health.
Methodology
Bone marrow transplantations were performed using different mouse models to study the effects of PLTP on atherosclerosis.
Participant Demographics
Male mice were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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