MicroRNAs in Cancer
Author Information
Author(s): Hwang H-W, Mendell J T
Primary Institution: The Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Hypothesis
How do microRNAs influence tumorigenesis by acting as oncogenes and tumor suppressors?
Conclusion
Dysregulation of microRNA expression is a frequent occurrence in diverse types of cancer, highlighting their potential utility for diagnostic and prognostic applications.
Supporting Evidence
- MicroRNAs regulate 30% of genes in the human genome.
- Abnormal miRNA expression is a common feature of human malignancies.
- More than half of miRNAs are located at sites in the human genome that are frequently altered in cancer.
Takeaway
MicroRNAs are tiny molecules that help control how cells grow and die, and when they don't work right, they can lead to cancer.
Methodology
This review discusses the roles of microRNAs in regulating cellular functions and their implications in cancer.
Limitations
The review does not provide original experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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