Mapping a Gene for Rheumatoid Arthritis on Chromosome 18q21
Author Information
Author(s): William Tapper, Andrew Collins, Newton E Morton
Primary Institution: Human Genetics Division, University of Southampton
Hypothesis
Can CHROMSCAN effectively identify significant SNPs associated with rheumatoid arthritis?
Conclusion
The study provides significant evidence for a determinant of rheumatoid arthritis in a 36-kb interval on chromosome 18q21.
Supporting Evidence
- Single chi-square analyses identified 125 SNPs with p < 0.05.
- None of the SNPs remained significant after Bonferroni correction.
- CHROMSCAN identified a significant region with p = 0.01259.
- Most association evidence came from females with an age of onset less than 40.
Takeaway
Researchers found a part of a gene on chromosome 18 that might be linked to rheumatoid arthritis, especially in younger women.
Methodology
The study used CHROMSCAN to analyze SNPs in a 10-Mb region and performed permutation tests for significance.
Potential Biases
Potential bias due to the stratification of cases by gender and age of onset.
Limitations
The study's findings are based on a specific population and may not be generalizable.
Participant Demographics
Participants included 460 cases and 460 controls matched for age and gender.
Statistical Information
P-Value
0.01259
Confidence Interval
53296 to 53332 kb
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website