A Pathway-Based View of Human Diseases and Disease Relationships
2009
Understanding Relationships Between Human Diseases
Sample size: 1028
publication
Evidence: high
Author Information
Author(s): Li Yong, Agarwal Pankaj
Primary Institution: GlaxoSmithKline R&D
Hypothesis
How are different human diseases related based on their underlying biology?
Conclusion
The study identified numerous disease relationships based on shared biological pathways, suggesting new insights into disease classification and treatment.
Supporting Evidence
- 4,195 candidate disease associated genes were identified for 1,028 diseases.
- On average, about 50% of disease associated genes of a disease are statistically mapped to pathways.
- A disease network was generated consisting of 591 diseases and 6,931 disease relationships.
Takeaway
This study shows that many diseases are connected because they share similar biological pathways, which can help us understand and treat them better.
Methodology
The study used literature mining to identify disease-associated genes and mapped them to biological pathways to create a disease network.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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