Increased Circulating Endothelial Progenitors in VHL Disease and Renal Cell Carcinoma
Author Information
Author(s): Bhatt R S, Zurita A J, O'Neill A, Norden-Zfoni A, Zhang L, Wu H K, Wen P Y, George D, Sukhatme V P, Atkins M B, Heymach J V
Primary Institution: Beth Israel Deaconess Medical Center
Hypothesis
Circulating endothelial progenitors and their ratio to mature endothelial cells would be altered in renal cell carcinoma patients but not in von Hippel-Lindau patients without renal cell carcinoma.
Conclusion
Circulating endothelial progenitors were elevated in renal cell carcinoma, but not in patients with von Hippel-Lindau disease without renal cell carcinoma.
Supporting Evidence
- Circulating endothelial progenitors were found to be higher in renal cell carcinoma patients compared to healthy controls.
- CEP counts decreased after nephrectomy in patients with non-metastatic sporadic RCC.
- Patients with VHL disease without RCC had lower CEP counts than those with RCC.
Takeaway
This study found that people with a type of kidney cancer have more special cells in their blood that help make new blood vessels, which could help doctors track the disease.
Methodology
Multicolour flow cytometry was used to enumerate circulating endothelial cells in patients with renal cell carcinoma, von Hippel-Lindau disease, and healthy subjects.
Limitations
The study had a small sample size and focused primarily on specific patient cohorts.
Participant Demographics
Patients included those with von Hippel-Lindau disease, sporadic renal cell carcinoma, and healthy control subjects.
Statistical Information
P-Value
P<0.01; P=0.04; P=0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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