Assessing the Role of CD103 in Immunity to an Intestinal Helminth Parasite
2011
The Role of CD103 in Intestinal Helminth Immunity
Sample size: 12
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Mullaly Sarah C., Burrows Kyle, Antignano Frann, Zaph Colby
Primary Institution: The Biomedical Research Centre, University of British Columbia
Hypothesis
Is CD103 necessary for protective immunity against intestinal helminth infections?
Conclusion
CD103 is not required for developing intestinal immunity during helminth infection.
Supporting Evidence
- CD103-deficient mice showed no significant difference in parasite burden compared to control mice.
- Absence of CD103 did not affect the frequency of Treg cells in the intestine.
- CD103−/− mice developed an earlier T cell response but resolved infection similarly to control mice.
Takeaway
The study found that mice without CD103 can still fight off intestinal worms just as well as those with it.
Methodology
The study used CD103-deficient mice and assessed their immune responses to Trichuris muris infection.
Limitations
The study may not fully account for other compensatory mechanisms in immune response.
Participant Demographics
C57BL/6 and CD103−/− mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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