Reaction of Ruthenium with Acyclovir
Author Information
Author(s): Aglaia Koutsodimou, Giovanni Natile
Primary Institution: NCSR Demokritos, Institute of Physical Chemistry
Hypothesis
How do cis- and trans-dichlorotetra(dimethylsulfoxide)ruthenium(II) react with the antiviral drug acyclovir?
Conclusion
The study found that both cis and trans isomers of ruthenium react with acyclovir to form monoadducts and bisadducts, with the trans isomer forming monoadducts more rapidly.
Supporting Evidence
- The reaction products from both isomers showed identical NMR spectra.
- The trans isomer produced monoadducts more quickly than the cis isomer.
- Both isomers formed a bisadduct even in excess of the ruthenium substrate.
Takeaway
The researchers looked at how two types of a metal compound interact with a medicine, finding that one type reacts faster than the other.
Methodology
NMR spectroscopy was used to monitor the reactions of cis- and trans-[RuC12(DMSO)4] with acyclovir in aqueous solutions at different temperatures and molar ratios.
Limitations
The study primarily focuses on the chemical behavior in aqueous solutions and does not explore in vivo effects.
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