Predictive Factors of Long-Term Radiographic Outcome in Early Rheumatoid Arthritis
Author Information
Author(s): Natacha Courvoisier, Maxime Dougados, Alain Cantagrel, Philippe Goupille, Olivier Meyer, Jean Sibilia, Jean Pierre Daures, Bernard Combe
Primary Institution: Service de Rhumatologie, Hôpital Saint Antoine, Paris, France
Hypothesis
What are the predictive factors of long-term radiographic outcome in early rheumatoid arthritis?
Conclusion
Baseline radiographic score, ESR, and ACPA are the best predictive factors of 10-year radiographic outcome in early rheumatoid arthritis.
Supporting Evidence
- Baseline erosion score was identified as the most important prognostic factor.
- 69.6% of patients showed significant progression in total radiographic score over 10 years.
- HAQ disability was associated with disease activity but not with joint damage.
Takeaway
Doctors can predict how rheumatoid arthritis will affect patients in the long run by looking at certain early signs, like X-ray results and blood tests.
Methodology
A cohort of 191 patients with early RA was followed for 10 years, using univariate analysis and logistic regression to identify predictive factors.
Potential Biases
Potential bias due to loss of follow-up and missing data.
Limitations
Some patients were lost to follow-up, and not all baseline data were available for every patient.
Participant Demographics
80.3% female, mean age 50.4 years, mean disease duration 3.9 months.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI = 1.78 to 17.86
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website