Metabolism of Ifosfamide During a 3-Day Infusion
Author Information
Author(s): J.M. Hartley, L. Hansen, S.J. Harland, P.W. Nicholson, F. Pasini, R.L. Souhami
Primary Institution: University College London Medical School
Hypothesis
The study aims to determine the patterns of excretion and amounts of urinary metabolites during ifosfamide therapy.
Conclusion
The study found that the proportion of urinary drug products in the form of ifosfamide decreased over three days, while the amounts of its metabolites increased.
Supporting Evidence
- The proportion of urinary drug products in the form of ifosfamide fell considerably over the course of the 3 days.
- Urinary dechloroethyl metabolites correlated positively with each other and negatively with carboxyifosfamide.
- With successive cycles, the amount of 2-dechloroethylifosfamide and isophosphoramide mustard increased by about 10% per course.
Takeaway
Doctors studied how a cancer drug called ifosfamide is broken down in the body by looking at patients' urine over three days.
Methodology
Urinary drug metabolites were measured in patients receiving ifosfamide by continuous infusion over three days.
Limitations
The study did not find evidence for genetic polymorphism affecting metabolite production.
Participant Demographics
21 patients (6 women and 15 men) with various malignancies, primarily Ewing's sarcoma.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website