Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522
1999
Inhibition of Colon Cancer Spread in Mice by COX-2 Inhibitor
publication
Evidence: moderate
Author Information
Author(s): Tomozawa S, Nagawa H, Tsuno N, Hatano K, Osada T, Kitayama J, Sunami E, Nita M E, Ishihara S, Yano H, Tsuruo T, Shibata Y, Muto T
Primary Institution: University of Tokyo
Hypothesis
Does selective inhibition of COX-2 reduce haematogenous metastasis of colon cancer?
Conclusion
Selective COX-2 inhibitors may help reduce the spread of colon cancer in mice.
Supporting Evidence
- COX-2 is expressed at high levels in colorectal tumors.
- Selective inhibition of COX-2 inhibits colon cancer cell growth.
- Mice treated with JTE-522 had significantly reduced lung metastatic nodules.
Takeaway
This study found that a specific medicine can help stop colon cancer from spreading in mice.
Methodology
Mice were injected with colon cancer cells and treated with a COX-2 inhibitor, then lung metastases were compared.
Participant Demographics
BALB/c mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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