Lactulose Treatment for Hepatic Encephalopathy in Children with Cirrhosis
Author Information
Author(s): Praveen Sharma, Barjesh C. Sharma
Primary Institution: G. B. Pant Hospital, New Delhi, India
Hypothesis
Lactulose therapy will improve hepatic encephalopathy in children with cirrhosis.
Conclusion
Lactulose therapy causes complete recovery from hepatic encephalopathy in 73% of pediatric patients with cirrhosis.
Supporting Evidence
- 73% of children treated with lactulose had complete recovery from hepatic encephalopathy.
- Significant differences in mean arterial pressure, serum sodium, and serum creatinine were observed between responders and non-responders.
Takeaway
This study found that giving lactulose to kids with liver problems helped most of them feel better from their brain issues caused by the liver.
Methodology
Retrospective analysis of cirrhotic patients under 18 years with hepatic encephalopathy treated with lactulose.
Limitations
The study did not analyze arterial ammonia or gut flora changes.
Participant Demographics
The study included 22 children with cirrhosis, aged approximately 13.5 years, with a sex ratio of 8 males to 14 females.
Statistical Information
P-Value
P=0.003 for mean arterial pressure difference
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website