Fr-TM-align: a new protein structural alignment method based on fragment alignments and the TM-score
2008
Fr-TM-align: A New Protein Structural Alignment Method
Sample size: 400
publication
Evidence: high
Author Information
Author(s): Pandit Shashi Bhushan, Skolnick Jeffrey
Primary Institution: Georgia Institute of Technology
Hypothesis
Fr-TM-align will provide better structural alignments compared to existing methods like TM-align.
Conclusion
Fr-TM-align outperforms TM-align and CE in generating structural alignments with higher accuracy and coverage.
Supporting Evidence
- Fr-TM-align showed a ~9% improvement in TM-score compared to TM-align.
- The algorithm achieved a ~7% increase in coverage of aligned residues.
- Statistical tests confirmed the significance of the improvements in alignment quality.
Takeaway
Fr-TM-align is a new computer program that helps scientists compare protein shapes better than older methods.
Methodology
The Fr-TM-align algorithm uses fragment alignments and dynamic programming to improve the quality of protein structure alignments.
Limitations
Fr-TM-align is computationally more expensive and slower than TM-align.
Statistical Information
P-Value
<< 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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