BLOOD MULTIOMIC PROFILES REFLECT SYSTEM STATES OF ORGANS IN MICE
2024
Blood Profiles Show How Organs Age in Mice
publication
Author Information
Author(s): Watanabe Kengo, Pflieger Lance, Robinson Max, Lapidus Jodi, Miller Richard, Fiehn Oliver, Moritz Robert, Rappaport Noa
Primary Institution: Institute for Systems Biology
Hypothesis
Can blood omics data reflect alterations in organ systems related to aging?
Conclusion
Blood omics can help identify and characterize different states of organs involved in aging and longevity.
Supporting Evidence
- Blood omics data can reflect alterations in organ systems.
- The study used data from kidney, liver, gastrocnemius muscle, and plasma samples.
- Machine learning models revealed differences between sexes and prolongevity interventions.
Takeaway
Scientists studied blood samples from mice to see how different organs age, and they found that blood tests can show changes in organ health.
Methodology
Used blood omics data from various organ samples and applied correlation analysis and machine learning models.
Participant Demographics
Mice from the NIA Longevity Consortium.
Digital Object Identifier (DOI)
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