Effects of rTMS on Behavior in Alzheimer’s Disease Mice
Author Information
Author(s): Kraybill Eric P., Mojabi Fatemeh S., Heath Alesha M., Spikes Cierra R., Beard Charlotte, McNerney M. Windy, Ginsberg Stephen D.
Primary Institution: Mental Illness Research Education and Clinical Center (MIRECC), Department of Veteran Affairs
Hypothesis
rTMS would reduce hypoactivity and time spent in center in the open field task, while ANA12 would abolish this effect.
Conclusion
rTMS positively affects elements of hypoactivity in Alzheimer’s disease mice, but does not address all behavioral abnormalities.
Supporting Evidence
- 3xTg-AD mice spent more time in the center than B6 mice.
- 3xTg-AD-Sham mice injected with ANA12 traveled significantly less distance than B6-ANA12-Sham or B6-Vehicle-Sham mice.
- 3xTg-AD mice had significantly greater levels of BDNF and TrkB than wild-type mice.
Takeaway
Researchers tested a treatment called rTMS on mice with Alzheimer’s disease to see if it would help them move around more and behave better. It helped a bit, but not completely.
Methodology
The study involved 100 female mice, with treatments of rTMS or Sham and injections of ANA12 or Vehicle, followed by behavioral assessments.
Potential Biases
Potential bias due to the exclusion of mice based on inactivity and equipment malfunction affecting data collection.
Limitations
The study's sample size may have limited the results, and not all behaviors were evaluated for memory performance.
Participant Demographics
100 female mice aged 12 months, including 47 3xTg-AD and 53 B6 wildtype mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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