Low-Dose Bisphosphonate Therapy for Complex Regional Pain Syndrome
Author Information
Author(s): Abe Yasuhisa, Iba Kousuke, Takada Junichi, Wada Takuro, Yamashita Toshihiko
Primary Institution: Sapporo Medical University School of Medicine
Hypothesis
Can low-dose bisphosphonate therapy improve pain and osteoporotic changes in patients with complex regional pain syndrome type I?
Conclusion
Low-dose oral bisphosphonate therapy significantly improved pain and regional osteoporotic changes in two patients with complex regional pain syndrome type I.
Supporting Evidence
- Both patients experienced significant pain reduction after starting bisphosphonate therapy.
- Radiographic findings showed improvement in osteoporotic changes after treatment.
- The effects of treatment lasted for over 30 months without further medication.
Takeaway
Two men with severe foot and ankle pain got better after taking a low dose of medicine that helps bones, showing that it can help with their pain.
Methodology
The study involved two case reports where patients were treated with low-dose bisphosphonates and followed for over 30 months.
Limitations
The improvement could be due to spontaneous recovery rather than the treatment.
Participant Demographics
Both participants were 48-year-old Japanese men.
Digital Object Identifier (DOI)
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