New Software for Simulating Genetic Data in Pedigrees
Author Information
Author(s): Mathieu Lemire
Primary Institution: McGill University and Genome Quebec Innovation Centre
Hypothesis
Can a two-step algorithm improve the simulation of a large number of marker loci linked to trait loci in pedigrees?
Conclusion
The new method allows for the efficient simulation of many marker loci conditional on observed trait values in families.
Supporting Evidence
- The new method can simulate a large number of marker loci linked to trait loci efficiently.
- It allows for the simulation of both qualitative and quantitative traits.
- The software can handle complex pedigrees with multiple founders.
Takeaway
This study introduces a new way to simulate genetic data that helps researchers understand how traits are passed down in families.
Methodology
A two-step algorithm using SLINK to simulate genotypes at the trait locus and then generating marker alleles in the founders.
Limitations
The implementation is limited to pedigrees with at most 16 founders and can only generate a limited number of alleles per marker.
Digital Object Identifier (DOI)
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