The Relationship Between Pulmonary Fibrosis and Thrombotic Events
Author Information
Author(s): Cenerini Giovanni, Chimera Davide, Pagnini Marta, Bazzan Erica, Conti Maria, Turato Graziella, Celi Alessandro, Neri Tommaso
Primary Institution: Università degli Studi di Pisa
Hypothesis
The review explores the bidirectional relationship between pulmonary fibrosis and thrombosis.
Conclusion
The study highlights the complex interplay between pulmonary fibrosis and thrombotic events, suggesting that both conditions exacerbate each other.
Supporting Evidence
- Idiopathic pulmonary fibrosis (IPF) is linked to a higher risk of thrombotic events.
- Coagulation factors can promote fibrosis, while fibrosis can activate thrombotic pathways.
- Extracellular vesicles play a significant role in linking fibrosis and coagulation.
- Anticoagulants may benefit IPF patients, but evidence from prospective trials is limited.
- Targeting specific coagulation pathways may offer new therapeutic strategies for IPF.
Takeaway
Pulmonary fibrosis can make people more likely to have blood clots, and blood clots can make pulmonary fibrosis worse.
Methodology
This is a narrative review discussing epidemiological evidence, mechanisms, and therapeutic implications.
Limitations
The review is based on existing literature and may not include all recent studies.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website